Nausea Drugs Linked To Heightened Risk Of Stroke
Photo Credit: Karolina Grabowska Photo Sourced From: Pexels
Drugs known as antidopaminergic antiemetics (ADAs) that are widely used to relieve nausea and vomiting caused, for instance, by migraine, chemotherapy or radiotherapy, and after surgery are associated with an increased risk of ischaemic stroke, finds a study published by The BMJ today.
The results show that all three ADAs studied (domperidone, metopimazine, and metoclopramide) were associated with an increased risk, especially in the first days of use, but the highest increase was found for metopimazine and metoclopramide. The researchers suggest that the potential action of ADAs on blood flow to the brain could explain this higher risk.
Like antipsychotics, ADAs are antidopaminergic drugs—they work by blocking dopamine activity in the brain. Antipsychotics have been associated with an increased risk of ischaemic stroke, but whether this risk could extend to other antidopaminergics including ADAs is not known.
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